Does a positive ANA with 1:640 titer mean I have lupus?
Understanding high antibody levels, their target DNA, and why additional testing is needed to identify the specific type and cause.
Susan Leclair, PhD, CLS (NCA)Answer from the Expert: You do have the presence of a high level of antibody but to which part of the DNA it is directed or which type of antibody is not known. Your provider must determine that from your physical concerns and history as well as additional tests. You should ask your physician to explain what led to these tests and how they explain your situation.
Further Explanation: It is very rare for any single test to be strong enough to have a clear cut connection between a single disease and a diagnosis. In part that is because of the limitations of the tests but, much more importantly, is that your provider must take that test result and apply it to the history, physical, patient complaints, types of medications (the list goes on and on) of that unique patient. Only when he/she puts all of that information together can a conclusion be reached.
The ANA or anti-nuclear antibody test is looking for a specific antibody that is directed against the patient's own DNA. One limitation here is that there are several types of auto-antibodies (made by you and directed against your own cells) and they can cause an increase in the titer of the antibody tested for here."
This information is not a substitute for, nor does it replace professional medical advice, diagnosis, or treatment. If you have any concerns or questions about your health, you should always consult with a healthcare professional.